Indian scientists have given a new life to sulfapyridine, an arthritis medicine by the development of innovative drug delivery method for arthritis particularly to get rid of side effects associated with the medicine. Moreover, arthritis is the inflammation of one or more joints that causes pain and stiffness that can worsen with age. The most common types of arthritis are rheumatoid and osteoarthritis arthritis.
According to the researchers from Lovely Professional University (LPU), Punjab, Sulfapyridine is the third oldest drug still in use in the treatment of rheumatoid arthritis.
The treatment involving long term use of Sulfapyridine drug results in side effects such as nausea or vomiting, anxiety, dizziness, rashes, and abdominal pain. As the drug molecules have side effects due to its higher dose. The scientists from the School of Pharmaceutical Sciences (LPU) have developed a formulation which can be delivered directly to the site of action which is a safer option to deliver drug without causing long term side effects. This research study has been published in the journal “Materials Science and Engineering C.”
The development of the prodrug of sulfapyridine exhibits better retention in liposomes, as compared to the drug, thus reduces the symptoms of inflammation. The prodrug treatment is operated by injecting the affected area of the patient instead of oral consumption. The process of injection retains the medication in the affected area without spreading it into the other body parts. The successful retention of the drug at the injection site for a longer time requires a very low dose, therefore has no side effects along with the necessity of very less dose frequency.
The pre-clinical trials and testing of the drug delivery mechanism have been conducted successfully by the LPU research team including Kapoor, Monica Gulati, and Sachin K. Singh. The team has also conducted a study to understand the efficacy of sulfapyridine-derived liposomes. As per the findings, arthritic rats, prodrug liposomes were found to reverse the symptoms of inflammation, including the levels of biochemical markers. The research was held out in collaboration with the researchers from Fortis Hospital (Ludhiana) and JSS College of Pharmacy (Ooty, Tamil Nadu).
Moreover, at present, sulfapyridine is used in the form of sulfasalazine and recommended orally in a high dose which has few side effects owing to its less exposure to the non-targeted sites.
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